Pics of ccmb scientists

Yogendra sharma


shashi now professor in iiser pune



Imran


Ramesh sonti


Shivaji


Thangaraj K


Lalji singh


amit chattopadhyay

Utpal bhadra


jyotsana dhawan
Jyotsna Dhawan is a senior scientist at the Centre for Cellular and Molecular Biology, Hyderabad India. Jyotsna is a leading young researcher at this top Indian Research Institute, working on muscle stem cells and molecular regulation in mammalian systems.

Jyotsna Dhawan received her PhD from Boston University School of Medicine in 1991 studying growth control in fibroblasts and myoblasts. After postdoctoral work at Stanford University investigating skeletal muscle as a target tissue for cell and gene therapy, she established a group at CCMB in 1996 to study the biology of adult skeletal muscle stem cells, in particular, the importance of quiescence in muscle stem cell function. Research in Jyotsna’s group is currently focused on intrinsic chromatin regulatory mechanisms that couple the cell cycle and myogenic differentiation, and signaling pathways that convey information from extrinsic sources.



Rakesh mishra



Mohan rao

Dr. guruprasad's group

About Dr. guruprasad

K. Guruprasad, Ph.D (Univ. of London, U.K.)
Scientist & Co-ordinator, Bioinformatics,
Centre for Cellular and Molecular Biology (CCMB),
Uppal Road, Hyderabad, 500 007, INDIA.


Positions held:

1983-1985: Project Assistant, Society of Biological Chemists in India, Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad - 500 007, India.
1985-1990: Scientist, Bioinformatics, Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad - 500 007, India.
1990-1997: Research Fellow, Department of Crystallography, Birkbeck College, University of London & Department of Biochemistry, University of Cambridge, Cambridge, U.K.
1997-1998: Faculty member (Reader), Bioinformatics Centre, University of Pune, Ganeshkhind, Pune - 411 007, India. Coordinated the first batch students of the One-Year Advanced Diploma Course in Bioinformatics programme.
1998-2000: Head, Bioinformatics & Manager, European Molecular Biology Network (EMBnet) India Node. Centre for DNA Fingerprinting and Diagnostics (CDFD), Nacharam, Hyderabad - 500 076, India. Established the Bioinformatics infrastructure and led a Research group.
2000-2001: Head, Bioinformatics, gvkbio, Hyderabad. Helped promoters start-up this company.
2001- : Head, Bioinformatics, Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad - 500 007, India.

Anant patel's group

About ANANT

Dr. Anant B. Patel obtained his master in Chemistry with Physical Chemistry specialization from Department of Chemistry, Banaras Hindu University in 1993 and Ph. D. in Chemistry entitled "NMR Studies of Biomolecular Systems" from the Department of Chemical Sciences, Tata Institute of Fundmamental Research / Mumbai University, Mumbai in 1999. He was a Postdoctoral Research Associate at the Magnetic Resonance Research Centre (MRRC), Yale University, New Haven, Connecticut, USA from 1999-2003. He served as Associate Research Scientist at Yale MRRC from 2003-2006.

He joined the Centre for Cellular and Molecular Biology, Hyderabad as a senior scientist in June 2006. He has started in vivo NMR imaging and spectroscopy program in the institute and carrying out research in the field of in vivo NMR spectroscopy. His research interests are in trying to understand metabolic basis of various diseases/disorders related with nervous system. One major area of focus in his laboratory is in understanding how excitatory and inhibitory neurotransmission are affected during normal ageing and in Alzeimer's disease. The other areas of research in his laboratory include understanding the brain energy metabolism in diabetes and identify the biomarker for the diagnosis of liver diseases.
Research Interest

Glutamate and gamma-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter, in central nervous system. It is well established that a neuronal astrocytic neurotransmitter cycle exists in the brain. In this cycle, neurotransmitter glutamate released from neurons into the synaptic cleft is taken up by astrocytes, converted to glutamine, and returned to neurons in this synaptic inactive form. In neurons glutamine is hydrolyzed to glutamate and re-packaged into vesicles, and ready for the next release. Similarly, GABA released from the inhibitory neurons also may be taken up by astrocytes, converted to glutamate and recycled to GABAergic neurons in the same way. This cycle is called neurotransmitter (glutamate/glutamine, GABA/glutamine) cycle. We have developed stable 13C isotope technique to quantify energetics of glutamaterigc and GABAergic neurotransmission in rodent brain in vivo.

Our current research work is focused on to understand the metabolic basis of various diseases related with central nervous system. The major goals of our studies are following:

1. Identify the atrophy in different brain regions during normal ageing and at various stage of Alzheimer's disease in mouse model.

2. Measure quantitatively the effects of normal ageing and Alzheimer's disease on the concentrations of the major cerebral metabolites specific to neuronal and astroglial cell in mouse model.

3. Determine the effects of normal ageing and Alzheimer's disease on the eneregics of glutamatergic (excitatory neuron), GABAergic neurons (inhibitory neuron) and astroglia.

4. Understand the role of caloric restricted diet and memory enhancing dugs in brain atrophy, cerebral metabolites and neurotransmitter energetics during normal ageing and in Alzheimer's disease.

5. Investigate cerebral metabolism in mouse model of diabetes.

6. Develop non-invasive NMR method for studying hepatic, diabetes, etc. diseases.

Imaran siddique group

Dr. Imran Siddiqi
Centre for Cellular and Molecular Biology(CCMB)
Uppal Road,Hyderabad-500 007
Andra Pradesh
India
Tel: +91 40 27192570
Fax: +91 40 27160591, 27160311
Email: imran@ccmb.res.in
Dr. Siddiqi obtained his M.Sc from Indian Institute of Technology, Bombay, in 1981, and his Ph.D from University of Oregon, under the guidance of Prof. Franklin Stahl, in 1989. Following postdoctoral work at Indian Institute of Science, Bangalore,he joined Centre for Cellular and Molecular Biology(CCMB) in 1992. Currently he is a group leader at CCMB.


Plant Developmental Biology

Research in the lab is mainly focused on the developmental biology of plant reproduction with an emphasis on the control of female meiosis and gametogenesis. The study of female gametophyte development is of special interest in that it affords the opportunity of addressing basic issues in plant developmental biology such as the generation of positional information leading to cell specification, and the role of cell interactions and programmed cell death, in the context of a small and well defined group of distinct and highly specialized cells that make up the female gametophyte.

The female gametophyte or embryo sac contains the egg cell and associated cells required for fertilization and development of the embryo and endosperm. In order to understand the molecular mechanisms underlying ovule and female gametophyte development in higher plants, we have taken a genetic approach starting with screens for mutants that affect female fertility using Arabidospsis as a model system. We also employ candidate gene approaches to address the function of Arabidopsis homologs of genes that are required for the control of meiosis in yeast.